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To isolate the metabolic changes directly associated with oxidative burst from those generally induced by stimulation, we compared the metabolomic profiles of neutrophils stimulated with zymosan, TNF-α, PsA or PMA for 30 min, with or without treatment with the NOX inhibitor DPI (Fig

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ROS are produced during normal cellular metabolism and can adversely affect critical biomolecules such as lipids, carbohydrates, proteins, and nucleic acids (Cetin Cakmak and Gulcin 2019)